The effect of antioxidant supplementation on bacterial translocation after intestinal ischemia and reperfusion

Redox Rep. 2017 Jan;22(1):1-9. doi: 10.1080/13510002.2016.1229893. Epub 2016 Oct 13.


The intestine is highly sensitive to ischemia/reperfusion (I/R) injury. Intestinal I/R may cause local tissue injury and disruption of the intestinal mucosal barrier, allowing the passage of viable bacteria and endotoxins from the gastrointestinal lumen to distant organs. This phenomenon, known as bacterial translocation (BT), may lead to systemic disorders with high morbidity and mortality. Oxidative stress mediators such as reactive oxygen species, polymorphonuclear neutrophils and nitric oxide are believed to contribute to the intestinal I/R injury. Many antioxidants have shown protective effects against I/R injury of various organs. The present article provides an overview of studies investigating the effect of antioxidant supplementation on BT after intestinal I/R.

Keywords: Bacterial translocation; NO toxicity; antioxidants; free radicals; intestinal ischemia; oxidative stress; reactive oxygen species; reperfusion injury.

Publication types

  • Review

MeSH terms

  • Animals
  • Antioxidants / metabolism*
  • Antioxidants / therapeutic use*
  • Bacterial Translocation / drug effects*
  • Free Radicals / metabolism
  • Humans
  • Intestinal Mucosa / metabolism
  • Intestinal Mucosa / microbiology
  • Intestinal Mucosa / pathology
  • Intestines / microbiology
  • Intestines / pathology
  • Malondialdehyde / metabolism
  • Nitric Oxide / metabolism
  • Oxidative Stress / drug effects
  • Reactive Oxygen Species / metabolism
  • Reperfusion Injury / drug therapy*
  • Reperfusion Injury / microbiology*


  • Antioxidants
  • Free Radicals
  • Reactive Oxygen Species
  • Nitric Oxide
  • Malondialdehyde