Development of the neuronal system containing neuropeptide Y in the rat hypothalamus

Int J Dev Neurosci. 1989;7(4):359-74. doi: 10.1016/0736-5748(89)90057-9.

Abstract

In the rat hypothalamus, neuropeptide Y-containing neurons first appeared on day 14.5 of gestation in the arcuate nucleus and in the dorsolateral hypothalamic area. Until birth neuropeptide Y-containing cell bodies increased in number in the arcuate, dorsomedial-lateral and paraventricular nuclei, but disappeared thereafter, but some cells remaining in the arcuate nucleus. In animals treated neonatally with monosodium L-glutamate to destroy the arcuate nucleus, neuropeptide Y-immunoreactivity became evident in many cells scattered in the magnocellular paraventricular and dorsomedial-lateral hypothalamic nuclei on day 16 but not on days 60 and 12. These neuropeptide Y-immunoreactive neurons which appeared in the paraventricular nucleus were also vasopressin-positive. Neuropeptide Y fibers, on the contrary, remarkably diminished in number on day 16, particularly in the paraventricular and dorsomedial-lateral nuclei, and the medial preoptic area, but made a considerable recovery on days 60 and 120. Hence it is probable that, in normal ontogenetic progress, the development of the neuropeptide Y fibers in these areas is inhibitorily affected by that of arcuate neuropeptide Y neurons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / metabolism*
  • Animals
  • Arcuate Nucleus of Hypothalamus / embryology
  • Arcuate Nucleus of Hypothalamus / growth & development
  • Arcuate Nucleus of Hypothalamus / metabolism
  • Embryonic and Fetal Development*
  • Gestational Age
  • Glutamates / pharmacology*
  • Hypothalamus / embryology
  • Hypothalamus / growth & development
  • Hypothalamus / metabolism*
  • Male
  • Neuropeptide Y / metabolism*
  • Neuropeptide Y / physiology
  • Paraventricular Hypothalamic Nucleus / embryology
  • Paraventricular Hypothalamic Nucleus / growth & development
  • Paraventricular Hypothalamic Nucleus / metabolism
  • Rats
  • Rats, Inbred Strains
  • Sodium Glutamate / pharmacology*

Substances

  • Glutamates
  • Neuropeptide Y
  • Sodium Glutamate