Valproic Acid and Hepatic Steatosis: A Possible Link? About a Case Report

Psychopharmacol Bull. 2016 Aug 15;46(2):59-62.

Abstract

Background: Valproic acid is a mood-stabilizing anticonvulsant. Hepatic injuries are among the occasionally observed adverse effects of this medication.

Case presentation: We present the case of a 47-year-old man who had bipolar disorder for ten years and treated with valproic acid. He demonstrated elevated serum aminotransferases and ultrasonography revealed that hepatomegaly was suggestive of hepatic steatosis.

Conclusion: This case report stresses the importance of a complete drug history and the need for clinicians to be aware of the delayed onset of hepatic injuries.

Keywords: anticonvulsivant; bipolar disorder; hepatic steatosis; valproic acid.

Publication types

  • Case Reports

MeSH terms

  • Anticonvulsants / adverse effects*
  • Bipolar Disorder / drug therapy
  • Fatty Liver / chemically induced*
  • Humans
  • Male
  • Middle Aged
  • Valproic Acid / adverse effects*

Substances

  • Anticonvulsants
  • Valproic Acid