Dynamic Susceptibility Contrast MR Imaging in Glioma: Review of Current Clinical Practice

Magn Reson Imaging Clin N Am. 2016 Nov;24(4):649-670. doi: 10.1016/j.mric.2016.06.005. Epub 2016 Sep 14.

Abstract

Dynamic susceptibility contrast (DSC) MR imaging, a perfusion-weighted MR imaging technique typically used in neuro-oncologic applications for estimating the relative cerebral blood volume within brain tumors, has demonstrated much potential for determining prognosis, predicting therapeutic response, and assessing early treatment response of gliomas. This review highlights recent developments using DSC-MR imaging and emphasizes the need for technical standardization and validation in prospective studies in order for this technique to become incorporated into standard-of-care imaging for patients with brain tumors.

Keywords: Cerebral blood volume (CBV); Dynamic susceptibility contrast MR imaging (DSC-MR imaging); Glioblastoma; High-grade glioma; Prognosis; Pseudoprogression; Pseudoresponse; Response assessment.

Publication types

  • Review

MeSH terms

  • Brain Neoplasms / diagnostic imaging*
  • Contrast Media*
  • Glioma / diagnostic imaging*
  • Humans
  • Image Enhancement / methods*
  • Image Processing, Computer-Assisted / methods*
  • Magnetic Resonance Imaging / methods*

Substances

  • Contrast Media