Solubility of I-653, sevoflurane, isoflurane, and halothane in human tissues

Anesth Analg. 1989 Sep;69(3):370-3.


Tissue/blood partition coefficients of anesthetics are important indicators of the rate of tissue wash-in and wash-out, and wash-in and wash-out are determinants of the rates of induction of and recovery from anesthesia. In the present study of human tissues, we found that the tissue/blood partition coefficients (for brain, heart, liver, kidney, muscle, and fat) for the new anesthetic I-653 were smaller than those for isoflurane, sevoflurane, and halothane (anesthetics listed in order of increasing tissue/blood partition coefficients). For example, the respective brain/blood partition coefficients were 1.29 +/- 0.05 (mean +/- SD); 1.57 +/- 0.10; 1.70 +/- 0.09; and 1.94 +/- 0.17. This indicates that induction of and recovery from anesthesia with I-653 should be more rapid than with the other agents. The finding of a lower tissue/blood partition coefficient for I-653 parallels the previous finding of a lower blood/gas partition coefficient.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aging / metabolism
  • Anesthetics / metabolism*
  • Chromatography, Gas
  • Desflurane
  • Ethers / metabolism*
  • Halothane / metabolism*
  • Humans
  • Isoflurane / analogs & derivatives*
  • Isoflurane / metabolism*
  • Methyl Ethers*
  • Middle Aged
  • Sevoflurane
  • Solubility
  • Tissue Distribution


  • Anesthetics
  • Ethers
  • Methyl Ethers
  • Sevoflurane
  • Desflurane
  • Isoflurane
  • Halothane