Klebsiella pneumoniae Population Genomics and Antimicrobial-Resistant Clones

Trends Microbiol. 2016 Dec;24(12):944-956. doi: 10.1016/j.tim.2016.09.007. Epub 2016 Oct 11.


Antimicrobial-resistant Klebsiella pneumoniae (Kp) has emerged as a major global public health problem. While resistance can occur across a broad range of Kp clones, a small number have become globally distributed and commonly cause outbreaks in hospital settings. Here we describe recent comparative genomics investigations that have shed light on Kp population structure and the evolution of antimicrobial-resistant clones. These studies provide the basic framework within which genomic epidemiology and evolution can be understood, but have merely scratched the surface of what can and should be explored. We assert that further large-scale comparative and functional genomics studies are urgently needed to better understand the biology of this clinically important bacterium.

Keywords: Klebsiella pneumoniae; antimicrobial resistance; genomics; population structure.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use
  • Disease Outbreaks
  • Drug Resistance, Bacterial* / genetics
  • Evolution, Molecular
  • Humans
  • Klebsiella Infections / epidemiology
  • Klebsiella Infections / microbiology
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / genetics*
  • Metagenomics*
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism


  • Anti-Bacterial Agents
  • beta-Lactamases