15years of progress in gestational trophoblastic disease: Scoring, standardization, and salvage

Gynecol Oncol. 2017 Jan;144(1):200-207. doi: 10.1016/j.ygyno.2016.08.330. Epub 2016 Oct 13.


Significant improvements in treatment and the understanding of gestational trophoblastic neoplasia have occurred in the last 15years. These diseases are almost always curable, and refractory patients have more options for salvage therapy. Recent improvements in the understanding of epidemiology, diagnosis, and cell biology have resulted in changes in staging, advances in treatment options, and opportunities for fertility preservation.

Keywords: Choriocarcinoma; Gestational trophoblastic disease; Hydatidiform mole; Placental site trophoblastic tumor.

Publication types

  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Female
  • Fertility Preservation
  • Gestational Trophoblastic Disease / diagnosis*
  • Gestational Trophoblastic Disease / epidemiology
  • Gestational Trophoblastic Disease / pathology
  • Gestational Trophoblastic Disease / therapy*
  • Humans
  • Hysterectomy
  • Population Surveillance*
  • Pregnancy
  • Salvage Therapy / methods