Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Mar;57(2):487-497.
doi: 10.1007/s00394-016-1332-8. Epub 2016 Oct 15.

Bioactive Compounds From Regular Diet and Faecal Microbial Metabolites

Affiliations

Bioactive Compounds From Regular Diet and Faecal Microbial Metabolites

Tania Fernández-Navarro et al. Eur J Nutr. .

Abstract

Purpose: Short-chain fatty acids (SCFAs) formation by intestinal bacteria is regulated by many different factors, among which dietary fibre is currently receiving most attention. However, since fibre-rich foods are usually good dietary sources of phenolic compounds, which are also known to affect the microbiota, authors hypothesize that the regular intake of these bioactive compounds could be associated with a modulation of faecal SCFA production by the intestinal microbiota.

Methods: In this work, food intake was recorded by means of a validated Food Frequency Questionnaire. Fibres were determined using Marlett food composition tables, and phenolic compounds were obtained from Phenol-Explorer Database. Analysis of SCFA was performed by gas chromatography-flame ionization/mass spectrometry and quantification of microbial populations in faeces by quantitative PCR.

Results: Klason lignin and its food contributors, as predictors of faecal butyrate production, were directly associated with Bacteroides and Bifidobacterium levels, as well as lignans with Bacteroides. Also, anthocyanidins, provided by strawberries, were associated with faecal propionate and inversely related to Lactobacillus group.

Conclusions: These results support the hypothesis we put forward regarding the association between some vegetable foods (strawberries, pasta, lentils, lettuce and olive oil) and faecal SCFA. More studies are needed in order to elucidate whether these associations have been mediated by the bacterial modulatory effect of the bioactive compounds, anthocyanins, lignans or Klason lignin, present in foodstuffs.

Keywords: Fibre; Microbiota; Polyphenol; Short-chain fatty acids.

Similar articles

See all similar articles

Cited by 3 articles

References

    1. Nature. 2009 Oct 29;461(7268):1282-6 - PubMed
    1. Science. 2011 Oct 7;334(6052):105-8 - PubMed
    1. Anaerobe. 2006 Jun;12(3):140-7 - PubMed
    1. Br J Nutr. 2003 Sep;90(3):607-15 - PubMed
    1. Database (Oxford). 2010;2010:bap024 - PubMed

MeSH terms

LinkOut - more resources

Feedback