Long-term Outcomes of Pediatric Penetrating Keratoplasty for Herpes Simplex Virus Keratitis

Am J Ophthalmol. 2017 Jan:173:139-144. doi: 10.1016/j.ajo.2016.09.037. Epub 2016 Oct 14.

Abstract

Purpose: To analyze the characteristics and long-term outcomes of patients that underwent pediatric penetrating keratoplasty (PPK) for herpes simplex virus (HSV) keratitis.

Design: Retrospective, interventional, consecutive case series.

Methods: Observational report of outcomes and findings for 9 patients with history of HSV keratitis that underwent PPK and were followed in a single institution. Difference between the median preoperative and final best-corrected visual acuity (BCVA) was assessed and the outcomes are reported.

Results: We included 9 eyes; median age at the moment of the PPK was 14 years. The median initial BCVA was 20/400 (range 20/60 to hand motion) and final was 20/50 (range 20/30 to 20/400) (P < .05). Follow-up was a median of 94 months. Complications in these patients included glaucoma (1), graft rejection (1), recurrence of disease (1), and amblyopia (3). No graft failures were present.

Conclusion: The long-term outcomes with PPK for HSV keratitis in children provide improvement in BCVA when not compromised by amblyopia.

Publication types

  • Clinical Study

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Female
  • Follow-Up Studies
  • Graft Survival*
  • Humans
  • Infant
  • Keratitis, Herpetic / diagnosis
  • Keratitis, Herpetic / surgery*
  • Keratitis, Herpetic / virology
  • Keratoplasty, Penetrating / methods*
  • Male
  • Recurrence
  • Retrospective Studies
  • Simplexvirus*
  • Time Factors
  • Visual Acuity