Prognosis of alcohol-associated lactic acidosis in critically ill patients: an 8-year study

Sci Rep. 2016 Oct 17;6:35368. doi: 10.1038/srep35368.

Abstract

Lactic acidosis is common in critical care; by contrast, a subtype called alcohol-associated lactic acidosis (AALA) is rarely encountered. The primary purpose of this study was to determine the prognosis of AALA in critically ill patients and the second aim was to determine whether the survival was associated to the peak blood lactate concentration. An 8-year retrospective analysis of adult patients admitted to the intensive care unit (ICU) with AALA between January 2007 and December 2014 was considered in a tertiary care hospital. In total, 23 patients were analyzed and the median peak blood lactate level was 15.9 mmol/L. Only 2 patients (8.7%) presented peak blood lactate levels <10 mmol/L. In this study, 21 patients survived from ICU and hospital, the mortality rate was 8.7%. The result indicted the survival of AALA was not associated with peak blood lactate concentration although survivors still had a better lactate clearance rate per hour than non-survivors. Moreover, AALA patients with coexisting sepsis presenting higher lactate clearance rate and shorter lactate clearance time than those of AALA patients with solely sepsis-related lactic acidosis.

Publication types

  • Observational Study

MeSH terms

  • Acidosis, Lactic / complications
  • Acidosis, Lactic / physiopathology*
  • Adult
  • Aged
  • Alcoholism / complications
  • Alcoholism / physiopathology*
  • Critical Care
  • Critical Illness
  • Female
  • Hospital Mortality
  • Humans
  • Hydrogen-Ion Concentration
  • Intensive Care Units
  • Lactic Acid / blood
  • Male
  • Middle Aged
  • Prognosis
  • Retrospective Studies
  • Sepsis / blood
  • Tertiary Care Centers

Substances

  • Lactic Acid