Serum calprotectin is a biomarker of carotid atherosclerosis in patients with primary Sjögren's syndrome

Clin Exp Rheumatol. Nov-Dec 2016;34(6):1006-1012. Epub 2016 Sep 8.

Abstract

Objectives: We aimed to identify the association of carotid atherosclerosis with the traditional risk factors, disease features, cytokine profile, and calprotectin in patients with primary Sjögren's syndrome (pSS).

Methods: 63 primary pSS patients and 63 age- and sex-matched healthy controls underwent carotid ultrasound, clinical and laboratory examination. The presence of carotid plaques was taken as carotid atherosclerosis. The covariates of carotid atherosclerosis were identified in univariate and multivariate regressions.

Results: Patients with pSS had higher prevalence of carotid atherosclerosis (13% vs. 2%, p<0.05) and higher serum levels of calprotectin, tumour necrosis factor receptor 2 (TNF-R2), hepatocyte growth factor (HGF), and monocyte chemoattractant protein-1 (MCP-1) than controls. Sex, menopause, and the prevalence of traditional cardiovascular did not differ between groups (all p>0.05). In univariate analyses, serum calprotectin, most traditional cardiovascular (age, male sex, metabolic syndrome, hypertension, hypertriglyceridaemia, and serum creatinine), and some disease-associated risk factors (glucocorticoid or saliva substitute use, constitutional domain of Eular-Sjögren's syndrome disease activity index - EULAR) were associated with a higher risk for plaque. In a multivariate analysis, having pSS and higher serum calprotectin were associated with carotid atherosclerosis independent of traditional risk factors.

Conclusions: pSS have a higher prevalence of carotid atherosclerosis, which is associated with higher serum calprotectin level independent of traditional cardiovascular risk factors. Our findings suggest calprotectin as a biomarker of subclinical atherosclerosis in pSS.

MeSH terms

  • Adult
  • Atherosclerosis / blood
  • Atherosclerosis / complications
  • Atherosclerosis / diagnosis*
  • Biomarkers / blood
  • Carotid Artery Diseases / blood
  • Carotid Artery Diseases / complications
  • Carotid Artery Diseases / diagnosis*
  • Chemokine CCL2 / blood
  • Female
  • Hepatocyte Growth Factor / blood
  • Humans
  • Leukocyte L1 Antigen Complex / blood*
  • Male
  • Middle Aged
  • Receptors, Tumor Necrosis Factor, Type II / blood
  • Severity of Illness Index
  • Sjogren's Syndrome / blood
  • Sjogren's Syndrome / complications*

Substances

  • Biomarkers
  • Chemokine CCL2
  • Leukocyte L1 Antigen Complex
  • Receptors, Tumor Necrosis Factor, Type II
  • Hepatocyte Growth Factor