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, 95 (40), e5107

Prevalence of Placenta Previa Among Deliveries in Mainland China: A PRISMA-compliant Systematic Review and Meta-Analysis


Prevalence of Placenta Previa Among Deliveries in Mainland China: A PRISMA-compliant Systematic Review and Meta-Analysis

Dazhi Fan et al. Medicine (Baltimore).


Background: Placenta previa is characterized by the abnormal placenta overlying the endocervical os, and it is known as one of the most feared adverse maternal and fetal-neonatal complications in obstetrics.

Objectives: We aimed to obtain overall and regional estimates of placenta previa prevalence among deliveries in Mainland China.

Methods: The research was performed a systematic review, following the Meta-analysis of observational studies in epidemiology (MOOSE) guidelines for systematic reviews of observational studies, and the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement for reporting systematic reviews and meta-analysis. Electronic databases were searched and included hospital-based studies that reported placenta previa prevalence in Mainland China. Random-effects meta-analyses were used to pool prevalence estimates of placenta previa. Meta-regression analyses were performed to explore sources of heterogeneity across the included studies. For exploring the geographical distributions of placenta previa, the ArcGIS software (Esri) was used to construct the map of prevalence.

Results: A total of 80 articles and 86 datasets (including 1,298,548 subjects and 14,199 placenta previa cases) from 1965 through 2015 were included. The pooled overall prevalence of placenta previa among deliveries was 1.24% (95% confidence interval [CI], 1.12-1.36) in Mainland China during 1965 to 2015. And, the trend in the prevalence of placenta previa was steady. The occurrence rate of placenta previa in the region groups Northeast, North, Northwest, Central China, East, South, and Southwest was 1.20%, 1.01%, 1.10%, 1.15%, 0.93%, 1.42%, and 2.01%, respectively. The prevalence map based on a geographic information system showed an unequal geographic distribution.

Conclusions: The results showed that placenta previa is currently a high-burden disease in Mainland China. This review would be useful for the design of placenta previa planning and implementation adequate health care systems and treatment programs in Mainland China.

Conflict of interest statement

The author(s) received no specific funding for this work and declare that they have no competing interests. The authors have no conflicts of interest to disclose.


Figure 1
Figure 1
PRISMA flowchart showing the study selection process. PRISMA = preferred reporting items for systematic reviews and meta-analysis.
Figure 2
Figure 2
Pooled estimated prevalence of placenta previa in Mainland China with corresponding 95% confidence intervals from different survey year.
Figure 3
Figure 3
The provincial distribution of the prevalence of placenta previa on map of Mainland China.

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