Getting a grip on glycans: A current overview of the metabolic oligosaccharide engineering toolbox

Abstract

This review discusses the advances in metabolic oligosaccharide engineering (MOE) from 2010 to 2016 with a focus on the structure, preparation, and reactivity of its chemical probes. A brief historical overview of MOE is followed by a comprehensive overview of the chemical probes currently available in the MOE molecular toolbox and the bioconjugation techniques they enable. The final part of the review focusses on the synthesis of a selection of probes and finishes with an outlook on recent and potential upcoming advances in the field of MOE.

Keywords: Bio-orthogonal reactions; Chemical probes; Glycans; Glycobiology; Metabolic oligosaccharide engineering.