1 Intensive Care Unit, Wellington Regional Hospital, Wellington, New Zealand, and Medical Research Institute of New Zealand, Wellington, New Zealand; Department of Intensive Care, Austin Hospital, Faculty of Medicine, the University of Melbourne and Australian and New Zealand Intensive Care Research Centre, Monash University School of Public Health and Preventive Medicine, Melbourne, VIC, Australia; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy, and Vita-Salute San Raffaele University, Milan, Italy.