Vulvar, Perianal and Perineal Cancer After Hidradenitis Suppurativa: A Systematic Review and Pooled Analysis

Dermatol Surg. 2017 Jan;43(1):107-115. doi: 10.1097/DSS.0000000000000944.


Background: Hidradenitis suppurativa (HS) is a chronic inflammatory disease that frequently involves the perineal and perianal regions. The association between HS and malignant transformation is a rare but under recognized phenomenon.

Objective: This systematic review aims to summarize all available cases of vulvar and perianal/perineal cancer emerging in patients with HS, describing clinical and therapeutic particularities of these coexisting conditions in female patients.

Materials and methods: This systematic review and pooled analysis was performed in accordance with the PRISMA guidelines; end-of-search date was June 15, 2015.

Results: A total of 13 eligible articles were identified; 7 cases of vulvar cancer and 6 cases of perineal/perianal carcinomas in patients with HS were noted. A majority of published cases pertained to rather advanced carcinomas; only occasionally early stage carcinomas were identified. The optimal modifications in the treatment scheme of vulvar, perianal, and perineal cancer in patients with HS have not been established; detailed reporting of recurrence- and survival-related aspects is advised.

Conclusion: Vulvar, perianal, and perineal cancer represent a rare but serious complication of HS.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Buttocks
  • Carcinoma, Squamous Cell / etiology*
  • Carcinoma, Squamous Cell / secondary
  • Carcinoma, Squamous Cell / therapy
  • Female
  • Hidradenitis Suppurativa / complications*
  • Humans
  • Perineum*
  • Skin Neoplasms / etiology*
  • Skin Neoplasms / pathology
  • Skin Neoplasms / therapy
  • Vulvar Neoplasms / etiology*
  • Vulvar Neoplasms / pathology
  • Vulvar Neoplasms / therapy