Function of Cryopreserved Mesenchymal Stromal Cells With and Without Interferon-γ Prelicensing is Context Dependent

Stem Cells. 2017 May;35(5):1437-1439. doi: 10.1002/stem.2528. Epub 2016 Nov 10.

Abstract

Tailoring MSCs to fit the disease. Fresh, cryopreserved and, prelicensed cryopreserved MSC are all being explored to treat numerous diseases, but all are not suitable to treat all conditions. injury. "*" denotes preferred therapeutic strategy when both fresh MSC and cryo-MSC have shown utility in treating the disease but one is more efficacious or logistically suitable.

Abbreviations: CLI, critical limb ischemia; GvHD. graft versus host disease; I/R, ischemia reperfusion (I/R); OI, osteogenesis imperfecta.

Keywords: Cell transplantation; Immunosuppression; Indoleamine 2,3 dioxygenase; Mesenchymal stem cells; Retina.

Publication types

  • Letter

MeSH terms

  • Animals
  • Cryopreservation*
  • Humans
  • Indoleamine-Pyrrole 2,3,-Dioxygenase / metabolism
  • Interferon-gamma / pharmacology*
  • Mesenchymal Stem Cells / cytology*
  • Mesenchymal Stem Cells / drug effects
  • Mice, Inbred C57BL
  • Reperfusion Injury / pathology

Substances

  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Interferon-gamma