Pyranonaphthoquinones - Isolation, Biology and Synthesis: An Update

Nat Prod Rep. 2017 Jan 4;34(1):25-61. doi: 10.1039/c6np00080k.

Abstract

Covering: 2008 to 2015. A review on the isolation, biological activity and synthesis of pyranonaphthoquinone natural products from 2008-2015 is providedThis review discusses the isolation, biological activity and synthesis of pyranonaphthoquinone natural products, covering the years 2008-2015. The pyranonaphthoquinones are a group of metabolites sharing a common naphtho[2,3-c]pyran-5,10-dione ring system that have been isolated from a wide range of microorganisms, plants and insects. In addition to their synthetically challenging molecular structures, pyranonaphthoquinones exhibit a wide array of biological activity, including anti-bacterial, anti-fungal and anti-cancer properties. The therapeutic potential of these compounds has led to a dynamic interplay between total synthesis and biological evaluation.

Publication types

  • Review

MeSH terms

  • Biological Products* / chemical synthesis
  • Biological Products* / chemistry
  • Biological Products* / isolation & purification
  • Biological Products* / pharmacology
  • Molecular Structure
  • Naphthoquinones* / chemical synthesis
  • Naphthoquinones* / chemistry
  • Naphthoquinones* / isolation & purification
  • Naphthoquinones* / pharmacology

Substances

  • Biological Products
  • Naphthoquinones