Lung cancer is the leading cause of cancer mortality currently. Early diagnosis is crucial to the good prognosis of lung cancer. Evidence has shown that low-dose computed tomography (CT) screening can make the decline in the mortality of lung cancer. However, there are still many problems in the screening, such as, high false-positive rates, overdiagnosis and radiation exposure. As another non-invasive tumor screening method, blood-based tumor markers showed a high sensitivity and specificity in early diagnosis of lung cancer in recent years. How to establish a comprehensive mode for lung cancer screening by use existing screening methods, we need more clinical research.
肺癌是目前恶性肿瘤死亡的首要原因，早期诊断对肺癌的预后至关重要。研究显示低剂量计算机断层扫描（computed tomography, CT）筛查可以使肺癌的死亡率下降。但其存在的问题不可忽视，如过高的假阳性率、过度诊断、辐射效应等。作为一种肿瘤无创筛查方法，血液相关肿瘤标志物的检测，在肺癌早期诊断中显示出良好的敏感性和特异性。如何利用现有的筛查手段，建立肺癌筛查综合模式，需要更多大规模的临床研究。.