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. Jul-Sep 2016;9(3):157-164.
doi: 10.4103/0974-2077.191657.

Outcome of Intra-operative Injected Platelet-rich Plasma Therapy During Follicular Unit Extraction Hair Transplant: A Prospective Randomised Study in Forty Patients

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Free PMC article

Outcome of Intra-operative Injected Platelet-rich Plasma Therapy During Follicular Unit Extraction Hair Transplant: A Prospective Randomised Study in Forty Patients

Suruchi Garg. J Cutan Aesthet Surg. .
Free PMC article

Abstract

Context: Platelet-rich plasma (PRP) therapy is finding importance in aesthetic medicine.

Aim: The objective of this study was to study efficacy of PRP therapy in follicular unit extraction (FUE) hair transplant.

Materials and methods: It is a single-blind, prospective randomised study on 40 FUE hair transplant subjects, allocated in two groups (PRP and non-PRP) alternately. PRP was injected intra-operatively immediately after creating slits over the recipient area in PRP group; and normal saline in non-PRP group. Two groups were evaluated at 2, 4 and 8 weeks, 3 and 6 months of the procedure.

Statistical analysis: It was done using Chi-square test and test of significance was set as P < 0.05.

Results: In PRP group, all subjects had >75% hair regrowth at 6 months, density of >75% grafts was noticed in 12 patients at 4 weeks meaning reduced fall of transplanted hair during catagen phase. New hair growth started at 8 weeks in 16 patients and redness over recipient area completely disappeared in 19 patients at 3 months of surgery and activity in dormant follicles as fine thread like hair was noticed besides the thick transplanted hair in all subjects. In non-PRP group, four patients had >75% hair regrowth at 6 months; none showed >75% graft density at 4 weeks, and 13 subjects showed dormant follicle activity at 4 months. The number of patients having lengthier hairs was significantly more in PRP group.

Conclusion: Intra-operative PRP therapy is beneficial in giving faster density, reducing the catagen loss of transplanted hair, recovering the skin faster and activating dormant follicles in FUE transplant subjects.

Keywords: Follicular unit extraction hair transplant; hair; platelet-rich plasma therapy.

Figures

Figure 1
Figure 1
Platelet-rich plasma kit demonstrating buffy coat with staw coloured platelet-rich plasma in the bottleneck area of the tube
Figure 2
Figure 2
Image showing indigenous slitter with disposable 18G needles and wire holding forceps for maintaining uniform density
Figure 3
Figure 3
Follicle growth in platelet-rich plasma group (percentage of patients vs. number of weeks of treatment)
Figure 4
Figure 4
Follicle growth in non-platelet-rich plasma group (percentage of patients vs. number of weeks of treatment)
Figure 5
Figure 5
Effect of PRP on type of grafts (single or multiple)
Figure 6
Figure 6
Effect of PRP on length of shaft
Figure 7
Figure 7
Impact of PRP treatment on scalp redness
Figure 8
Figure 8
Hair growth without platelet-rich plasma treatment with comparative images over a period of 9 months. At 1 month interval almost 50% catagen fall of transplanted hair is noticed which is more severe in 2 months image, followed by visible new growth at 4 months image. Density is still less at 6 months interval, and final density is shown as in 9 months image
Figure 9
Figure 9
Hair growth with platelet-rich plasma treatment with comparative images over a period of 9 months. At 1 month interval more than 75% transplanted hair is in growing phase. At 2 months, there is relative thinning due to delayed catagen and breakage of hair strands above surface of skin. Images at 4 and 6 months show more density and length of transplanted hair as compared to non-platelet-rich plasma
Figure 10
Figure 10
Digital microscopic image showing new anagen hair at 2 months post transplant
Figure 11
Figure 11
Digital microscopic images of PRP And Non-PRP Group, evidence of persistent redness in Non-PRP Group at 3 Months Post Transplant

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