The prognostic value of histologic subtypes in primary extremity liposarcoma

Cancer. 1989 Oct 1;64(7):1514-20. doi: 10.1002/1097-0142(19891001)64:7<1514::aid-cncr2820640726>;2-2.


Patients with a localized primary liposarcoma of the extremity who were treated in Memorial Sloan-Kettering Cancer Center between 1968 and 1978 were studied. The prognosis of patients with extremity liposarcoma was analyzed according to histopathologic subtypes. A system of five subtypes was used; well-differentiated, myxoid, fibroblastic, lipoblastic, and pleomorphic liposarcomas. The 5-year treatment failure rates and survival rates were, respectively, 30% and 100% for well-differentiated, 25% and 88% for myxoid, 60% and 58% for fibroblastic, 100% and 40% for lipoblastic, and 64% and 56% for pleomorphic liposarcomas. Although local recurrence was present in all five subtypes, a significant increment in local failure was seen in patients with high-grade liposarcomas. Distant metastasis after the initial operation was not found in patients with well-differentiated liposarcoma and rare in the patients with myxoid liposarcoma. In contrast, 50% of the patients with fibroblastic, lipoblastic, and pleomorphic liposarcoma had a distant relapse within 5 years.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Extremities*
  • Female
  • Humans
  • Liposarcoma / classification
  • Liposarcoma / mortality
  • Liposarcoma / pathology*
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / pathology
  • New York
  • Prognosis
  • Soft Tissue Neoplasms / mortality
  • Soft Tissue Neoplasms / pathology*