Diffusion, Perfusion, and Histopathologic Characteristics of Desmoplastic Infantile Ganglioglioma

J Radiol Case Rep. 2016 Jul 31;10(7):1-13. doi: 10.3941/jrcr.v10i7.2715. eCollection 2016 Jul.


We present a case series of a rare tumor, the desmoplastic infantile ganglioglioma (DIG) with MRI diffusion and perfusion imaging quantification as well as histopathologic characterization. Four cases with pathologically-proven DIG had diffusion weighted imaging (DWI) and two of the four had dynamic susceptibility contrast imaging. All four tumors demonstrate DWI findings compatible with low-grade pediatric tumors. For the two cases with perfusion imaging, a higher relative cerebral blood volume was associated with higher proliferation index on histopathology for one of the cases. Our results are discussed in conjunction with a literature review.

Keywords: MRI; desmoplastic infantile ganglioglioma; diffusion; pediatric brain tumors; perfusion.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / pathology
  • Brain Neoplasms / surgery
  • Contrast Media
  • Diagnosis, Differential
  • Diffusion Magnetic Resonance Imaging
  • Female
  • Ganglioglioma / diagnostic imaging*
  • Ganglioglioma / pathology
  • Ganglioglioma / surgery
  • Humans
  • Infant
  • Male
  • Meglumine / analogs & derivatives
  • Organometallic Compounds


  • Contrast Media
  • Organometallic Compounds
  • gadobenic acid
  • Meglumine