Oligo(aryl-triazole)s CHCl- interactions guide chloride efficient and selective transmembrane transport

Chem Commun (Camb). 2016 Nov 18;52(89):13132-13135. doi: 10.1039/c6cc07792g. Epub 2016 Oct 20.

Abstract

A series of oligo(aryl-triazole)s (compounds 1-8) have been synthesized and served as transmembrane anion transporters by only CHCl- interactions. This work confirms their role in the activity of anion transport. By changing the lipophilicity and anion affinity of the compounds, efficient anion transport with remarkable Cl-vs. HCO3- selectivity was achieved.

MeSH terms

  • Chlorides / metabolism*
  • Hydrogen Bonding
  • Hydrophobic and Hydrophilic Interactions
  • Ion Transport
  • Lipid Bilayers / chemistry
  • Lipid Bilayers / metabolism
  • Polymers / chemistry*
  • Triazoles / chemistry*
  • Triazoles / metabolism

Substances

  • Chlorides
  • Lipid Bilayers
  • Polymers
  • Triazoles