Polarization of an electroactive functional film on titanium for inducing osteogenic differentiation

Zhengnan Zhou; Weiping Li; Tianrui He; Lei Qian; Guoxin Tan; Chengyun Ning

doi:10.1038/srep35512

Polarization of an electroactive functional film on titanium for inducing osteogenic differentiation

Sci Rep. 2016 Oct 20:6:35512. doi: 10.1038/srep35512.

Authors

Zhengnan Zhou^{1

2}, Weiping Li^{1

2}, Tianrui He^{1

2}, Lei Qian^{1

2}, Guoxin Tan³, Chengyun Ning^{1

2}

Affiliations

¹ School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China.
² Guangdong Key Laboratory of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou 510006, China.
³ Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.

Abstract

To enhance the surface bioactivity of titanium (Ti) prostheses, an electroactive polyvinylidene fluoride (PVDF) film was prepared on a Ti substrate to provide a mimetic of the electrical microenvironment, which facilitated the performance of cell functions. The results of cell proliferation and differentiation assays indicated that polarization of the PVDF-Ti (PTi) altered its surface charge, thus inducing adhesion, proliferation and osteogenic differentiation of cells. The polarized PVDF-Ti (PPTi) may therefore find applications in bone regeneration.

Publication types

Research Support, Non-U.S. Gov't