How to prepare a systematic review of economic evaluations for informing evidence-based healthcare decisions: data extraction, risk of bias, and transferability (part 3/3)

Expert Rev Pharmacoecon Outcomes Res. 2016 Dec;16(6):723-732. doi: 10.1080/14737167.2016.1246961. Epub 2016 Oct 21.


This article is part of the series "How to Prepare a Systematic Review (SR) of Economic Evaluations (EE) for Informing Evidence-based Healthcare Decisions" in which a five-step-approach for conducting a SR of EE is proposed. Areas covered: This paper explains the data extraction process, the risk of bias assessment and the transferability of EEs by means of a narrative review and expert opinion. SRs play a critical role in determining the comparative cost-effectiveness of healthcare interventions. It is important to determine the risk of bias and the transferability of an EE. Expert commentary: Over the past decade, several criteria lists have been developed. This article aims to provide recommendations on these criteria lists based on the thoroughness of development, feasibility, overall quality, recommendations of leading organizations, and widespread use.

Keywords: Systematic reviews; clinical practice guidelines; data-extraction; economic evaluations; quality appraisal; risk of bias.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Bias*
  • Cost-Benefit Analysis
  • Decision Making
  • Delivery of Health Care / economics
  • Delivery of Health Care / methods*
  • Evidence-Based Medicine / economics
  • Evidence-Based Medicine / methods
  • Humans
  • Research Design
  • Review Literature as Topic*