Tau Phosphorylation-Much More than a Biomarker

Sumihiro Maeda; Lennart Mucke

doi:10.1016/j.neuron.2016.10.011

Tau Phosphorylation-Much More than a Biomarker

Neuron. 2016 Oct 19;92(2):265-267. doi: 10.1016/j.neuron.2016.10.011.

Authors

Sumihiro Maeda¹, Lennart Mucke²

Affiliations

¹ Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA.
² Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA. Electronic address: lennart.mucke@gladstone.ucsf.edu.

PMID: 27764656
DOI: 10.1016/j.neuron.2016.10.011

Abstract

Lasagna-Reeves et al. (2016) demonstrate that preventing the kinase Nuak1 from phosphorylating the microtubule-associated protein tau reduces the level of potentially pathogenic tau species in brain, a novel therapeutic strategy that could help counteract Alzheimer's disease and several other neurological disorders.

MeSH terms

Alzheimer Disease*
Biomarkers
Brain
Phosphorylation
tau Proteins*

Substances

Biomarkers
tau Proteins