Nanofabricated Neural Probes for Dense 3-D Recordings of Brain Activity

Nano Lett. 2016 Nov 9;16(11):6857-6862. doi: 10.1021/acs.nanolett.6b02673. Epub 2016 Oct 21.


Computations in brain circuits involve the coordinated activation of large populations of neurons distributed across brain areas. However, monitoring neuronal activity in the brain of intact animals with high temporal and spatial resolution has remained a technological challenge. Here we address this challenge by developing dense, three-dimensional (3-D) electrode arrays for electrophysiology. The 3-D arrays constitute the front-end of a modular and configurable system architecture that enables monitoring neuronal activity with unprecedented scale and resolution.

Keywords: 3-D scalable packaging; Nanofabricated neural probes; brain mapping; high-density microelectrodes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / physiology*
  • Brain Mapping / instrumentation
  • Electrophysiological Phenomena
  • Electrophysiology / instrumentation*
  • Equipment Design
  • Humans
  • Imaging, Three-Dimensional / instrumentation
  • Microelectrodes
  • Molecular Probes / chemistry*
  • Molecular Probes / therapeutic use
  • Nanostructures / chemistry*
  • Neurons / physiology
  • Silicon / chemistry


  • Molecular Probes
  • Silicon