Elevated plasma levels of haptoglobin in Duchenne muscular dystrophy:electrophoretic variants in patients with a severe form of the disease

Electrophoresis. 1989 Jul;10(7):489-93. doi: 10.1002/elps.1150100707.


Analysis of plasma proteins of Duchenne muscular dystrophy (DMD) patients and normal age-matched boys using two dimensional gel electrophoresis and densitometry indicated a three-fold increase in the average haptoglobin level in DMD plasma. Two electrophoretic variants of haptoglobin in which the alpha 2 chain had more basic or more acidic spots were found in DMD patients with a rapidly progressing form of the disease. The basic variant was present in relatively low amount. Possible reasons for the elevated haptoglobin levels are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child, Preschool
  • Densitometry
  • Electrophoresis, Gel, Two-Dimensional / methods
  • Genetic Variation*
  • Haptoglobins / genetics
  • Haptoglobins / metabolism*
  • Hemoglobins / metabolism
  • Humans
  • Isoelectric Focusing
  • Male
  • Muscular Dystrophies / blood*
  • Peptide Mapping


  • Haptoglobins
  • Hemoglobins
  • haptoglobin-hemoglobin complex