Urinary l-type fatty acid-binding protein is a predictor of early renal function after partial nephrectomy

Ren Fail. 2017 Nov;39(1):7-12. doi: 10.1080/0886022X.2016.1244071. Epub 2016 Oct 21.

Abstract

Purpose: Urinary biomarkers of renal injury urinary may identify loss of renal function following nephron-sparing surgery (NSS). This study was designed to evaluate whether urinary l-type fatty acid-binding protein (l-FABP) is an early biomarker of loss of renal function after NSS. Specifically, the kinetics of urinary l-FABP level after NSS and its correlation with factors related to ischemic renal injury were analyzed.

Methods: This study prospectively evaluated 18 patients who underwent NSS between July and December 2014, including 12 who underwent laparoscopic and six who underwent robot-assisted partial nephrectomy. Urinary l-FABP concentrations were measured preoperatively and 1, 2, 3, 6, 12, 24, 48, and 72 h after renal artery declamping. Loss of renal function loss was calculated by comparing the effective renal plasma flow, as determined by 99mTc-mercaptoacetyltriglycine (MAG3) clearance, on the operated and normal sides. The decrease in estimated glomerular filtration rate from before surgery to six months after surgery was also measured.

Results: Urinary l-FABP concentration peaked within 2 h of declamping, which may quantify nephron damage caused by ischemia. The decrease in MAG3 reduction ratio correlated with both the ischemia time and peak urinary l-FABP concentration. Peak urinary l-FABP concentration showed a significant correlation with MAG3 reduction ratio.

Conclusions: l-FABP is a suitable urinary biomarker for predicting the extent of ischemic renal injury.

Keywords: l-Type fatty acid-binding protein; partial nephrectomy; renal function; renal injury; urinary biomarker.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers / urine
  • Fatty Acid-Binding Proteins / urine*
  • Female
  • Humans
  • Ischemia / physiopathology*
  • Japan
  • Kidney Function Tests
  • Laparoscopy / adverse effects*
  • Linear Models
  • Male
  • Middle Aged
  • Nephrectomy / adverse effects*
  • Nephrons / injuries*
  • Prospective Studies
  • Renal Artery / physiopathology*
  • Time Factors

Substances

  • Biomarkers
  • Fatty Acid-Binding Proteins