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. 2017 May;137(5):455-459.
doi: 10.1080/00016489.2016.1245865. Epub 2016 Oct 21.

Gastric-type H +,K +-ATPase in Mouse Vestibular End Organs

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Gastric-type H +,K +-ATPase in Mouse Vestibular End Organs

Masaya Takumida et al. Acta Otolaryngol. .

Abstract

Conclusion: Gastric type H+,K+-ATPase in the vestibular end organs may be of importance for K+ circulation and may also be related to pH regulation in vestibular end organs and endolymphatic sac.

Objective: To analyze the expression of gastric-type H+,K+-ATPase in normal mouse vestibular end organs.

Methods: 8 weeks old CBA/J mice were used in this study. The presence of gastric-type H+,K+-ATPase α and β in the vestibular end organs, viz. utricle, saccule, ampulla, vestibular ganglion, and endolymphatic sac, was investigated using immunohistochemistry.

Results: In the vestibular end organs, H+,K+-ATPase α and β were almost identical. H+,K+-ATPase was expressed in sensory cells, the basolateral surface of dark cells, fibrocytes, in vestibular ganglion cells, and in the upper region of the endolymphatic sac epithelial cells.

Keywords: Hydrogen, potassium-adenosine triphosphatase; immunohistochemistry; vestibular end organ.

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