[LDL-cholesterol and cardiovascular events: the lower the better?]

Wien Med Wochenschr. 2018 Apr;168(5-6):108-120. doi: 10.1007/s10354-016-0518-2. Epub 2016 Oct 21.
[Article in German]


For over 30 years, intensive research efforts investigated the role of LDL cholesterol in the pathogenesis of cardiovascular disease. In various settings, large statin trials showed an association between LDL cholesterol levels and cardiovascular event rates. This association is often referred to as the 'LDL cholesterol hypothesis'. More recent trials on agents with totally different modes of action confirmed this association and indicated a causal relationship between lower LDL cholesterol levels and improved cardiovascular outcomes. It has been proposed to term this causal relationship the 'LDL cholesterol principle'. It is to be expected that currently ongoing outcomes trials will further support the assumption of a causal relationship and will finally offer an armamentarium to therapists that will enable individualized treatment of dyslipidemias and their sequelae.

Keywords: Cardiovascular disease; Dyslipidaemia; Lowering of LDL-cholesterol.

Publication types

  • Review

MeSH terms

  • Cardiovascular Diseases / blood*
  • Cardiovascular Diseases / epidemiology
  • Cholesterol, LDL / blood*
  • Dyslipidemias
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use


  • Cholesterol, LDL
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors