The organisms colonizing a living host create together with their host a holobiome. The holobioms are networks of mutualistic interactions between host`s cells and microorganisms communities. The fungi are among these microorganisms and have been also well known to infect human and animals. These organisms are associated with a wide range of diseases as superficial or systemic mycoses. Fungi as colonizers can also modify host physiology and metabolism, energy acquisition, vitamin-cofactor availability, development and function of immune system, and even host behavior. The objective of this review is to familiarize with recent data concerning the role of fungi creating mammalian mycobiome in the maintenance of the host health status
Keywords: Fungi; holobiome; mycobiome; microbiota.