Characteristics of Autism Spectrum Disorder in Sotos Syndrome

J Autism Dev Disord. 2017 Jan;47(1):135-143. doi: 10.1007/s10803-016-2941-z.


Sotos syndrome is a congenital overgrowth disorder with an incidence of approximately 1 in 14,000. This study investigated behavioural characteristics of ASD within a large cohort of individuals with Sotos syndrome (n = 78). As measured by the Social Responsiveness Scale, second edition (SRS-2), 65 participants (83.33 %) met clinical cut-off (T-score ≥60). There was no significant gender difference in symptom severity. There was a significant effect of age, with lower scores observed in early childhood and adulthood, compared to childhood. Furthermore, individuals with Sotos syndrome appear to display a trait profile that is similar to that identified in ASD. Overall, these findings indicate that the majority of individuals with Sotos syndrome display clinically significant behavioural symptomatology associated with ASD.

Keywords: Autism spectrum disorder; Behaviour; Social responsiveness scale; Sotos syndrome.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Autism Spectrum Disorder / psychology*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Middle Aged
  • Severity of Illness Index*
  • Sex Factors
  • Sotos Syndrome / psychology*
  • Young Adult