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, 22 (2), 165-170

Polymorphisms and Expression of IL-32: Impact on Genetic Susceptibility and Clinical Outcome of Lung Cancer

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Polymorphisms and Expression of IL-32: Impact on Genetic Susceptibility and Clinical Outcome of Lung Cancer

Yanwen Wang et al. Biomarkers.

Abstract

Context: Polymorphisms of IL-32 related closely to tumoregenesis.

Materials and methods: Two IL-32 polymorphisms (rs12934561 and rs28372698) and mRNA expression were conducted by SNP genotype assay and real-time PCR in 423 lung cancer patients and 437 controls.

Results: T allele of rs28372698 associated significantly with poor prognosis in moderate and well-differentiated lung cancer patients. TT genotype of rs12934561 related closely to poor survival status in squamous carcinoma. IL-32 mRNA expression decreased in lung cancer.

Discussion and conclusion: Our study indicates the importance of IL-32 polymorphism and mRNA expression in susceptibility and influence of survival status in lung cancer.

Keywords: IL-32; lung cancer; prognosis; single-nucleotide polymorphism; survival status.

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