Coriandrum sativum Suppresses Aβ42-Induced ROS Increases, Glial Cell Proliferation, and ERK Activation

Am J Chin Med. 2016;44(7):1325-1347. doi: 10.1142/S0192415X16500749. Epub 2016 Oct 25.


Alzheimer's disease (AD), the most common neurodegenerative disease, has a complex and widespread pathology that is characterized by the accumulation of amyloid [Formula: see text]-peptide (A[Formula: see text]) in the brain and various cellular abnormalities, including increased oxidative damage, an amplified inflammatory response, and altered mitogen-activated protein kinase signaling. Based on the complex etiology of AD, traditional medicinal plants with multiple effective components are alternative treatments for patients with AD. In the present study, we investigated the neuroprotective effects of an ethanol extract of Coriandrum sativum (C. sativum) leaves on A[Formula: see text] cytotoxicity and examined the molecular mechanisms underlying the beneficial effects. Although recent studies have shown the benefits of the inhalation of C. sativum oil in an animal model of AD, the detailed molecular mechanisms by which C. sativum exerts its neuroprotective effects are unclear. Here, we found that treatment with C. sativum extract increased the survival of both A[Formula: see text]-treated mammalian cells and [Formula: see text]42-expressing flies. Moreover, C. sativum extract intake suppressed [Formula: see text]-induced cell death in the larval imaginal disc and brain without affecting A[Formula: see text]42 expression and accumulation. Interestingly, the increases in reactive oxygen species levels and glial cell number in AD model flies were reduced by C. sativum extract intake. Additionally, C. sativum extract inhibited the epidermal growth factor receptor- and A[Formula: see text]-induced phosphorylation of extracellular signal-regulated kinase (ERK). The constitutively active form of ERK abolished the protective function of C. sativum extract against the [Formula: see text]-induced eye defect phenotype in Drosophila. Taken together, these results suggest that C. sativum leaves have antioxidant, anti-inflammatory, and ERK signaling inhibitory properties that are beneficial for patients with AD.

Keywords: Alternative Medicine; Alzheimer’s Disease; Amyloid -Peptide; Animal Models; Coriandrum sativum; Extracellular Signal-Regulated Kinase.

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / metabolism
  • Amyloid beta-Peptides / metabolism
  • Animals
  • Anti-Inflammatory Agents*
  • Antioxidants*
  • Brain / cytology
  • Brain / metabolism
  • Cell Proliferation / drug effects*
  • Cells, Cultured
  • Coriandrum / chemistry*
  • Disease Models, Animal
  • Drosophila
  • Drosophila Proteins / metabolism
  • ErbB Receptors / metabolism
  • MAP Kinase Signaling System / drug effects
  • Neuroglia / cytology*
  • Neuroglia / metabolism*
  • Neuroprotective Agents*
  • Peptide Fragments / metabolism
  • Phosphorylation / drug effects
  • Phytotherapy*
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use*
  • Plant Leaves / chemistry
  • Reactive Oxygen Species / metabolism*
  • Receptors, Invertebrate Peptide / metabolism
  • Rutin / isolation & purification
  • Rutin / pharmacology
  • Rutin / therapeutic use


  • Amyloid beta-Peptides
  • Anti-Inflammatory Agents
  • Antioxidants
  • Drosophila Proteins
  • Neuroprotective Agents
  • Peptide Fragments
  • Plant Extracts
  • Reactive Oxygen Species
  • Receptors, Invertebrate Peptide
  • amyloid beta-protein (1-42)
  • Rutin
  • Egfr protein, Drosophila
  • ErbB Receptors