Prediction of post-operative pulmonary function after lobectomy for primary lung cancer: A comparison among counting method, effective lobar volume, and lobar collapsibility using inspiratory/expiratory CT

Eur J Radiol. 2016 Nov;85(11):1956-1962. doi: 10.1016/j.ejrad.2016.08.017. Epub 2016 Aug 26.

Abstract

Purpose: To compare the predictabilities of postoperative pulmonary function after lobectomy for primary lung cancer among counting method, effective lobar volume, and lobar collapsibility.

Methods: Forty-nine patients who underwent lobectomy for primary lung cancer were enrolled. All patients underwent inspiratory/expiratory CT and pulmonary function tests 2 weeks before surgery and postoperative pulmonary function tests 6-7 months after surgery. Pulmonary function losses (ΔFEV1.0 and ΔVC) were calculated from the pulmonary function tests. Predictive postoperative pulmonary function losses (ppoΔFEV1.0 and ppoΔVC) were calculated using counting method, effective volume, and lobar collapsibility. Correlations and agreements between ΔFEV1.0 and ppoFEV1.0 and those between ΔVC and ppoΔVC were tested among three methods using Spearman's correlation coefficient and Bland-Altman plots.

Results: ΔFEV1.0 and ppoΔFEV1.0insp-exp were strongly correlated (r=0.72), whereas ΔFEV1.0 and ppoΔFEV1.0count and ΔFEV1.0 and Pred. ΔFEV1.0eff.vol. were moderately correlated (r=0.50, 0.56). ΔVC and ppoΔVCeff.vol. (r=0.71) were strongly correlated, whereas ΔVC and ppoΔVCcount, and ΔVC and ppoΔVC insp-exp were moderately correlated (r=0.55, 0.42).

Conclusions: Volumetry from inspiratory/expiratory CT data could be useful to predict postoperative pulmonary function after lobectomy for primary lung cancer.

Keywords: Forecasting; Lung neoplasms; Lung volume measurement; Multidetector computed tomography; Respiratory function tests.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Exhalation
  • Female
  • Humans
  • Lung / diagnostic imaging
  • Lung / physiopathology*
  • Lung / surgery
  • Lung Neoplasms / surgery*
  • Male
  • Middle Aged
  • Postoperative Complications / diagnosis*
  • Postoperative Complications / physiopathology
  • Postoperative Period
  • Predictive Value of Tests
  • Reproducibility of Results
  • Respiratory Function Tests / methods
  • Respiratory Function Tests / statistics & numerical data
  • Tomography, X-Ray Computed / methods*