Mutation analysis of sporadic early-onset Alzheimer's disease using the NeuroX array

Neurobiol Aging. 2017 Jan;49:215.e1-215.e8. doi: 10.1016/j.neurobiolaging.2016.09.008. Epub 2016 Sep 23.

Abstract

We have screened sporadic early-onset Alzheimer's disease (sEOAD, n = 408) samples using the NeuroX array for known causative and predicted pathogenic variants in 16 genes linked to familial forms of neurodegeneration. We found 2 sEOAD individuals harboring a known causative variant in PARK2 known to cause early-onset Parkinson's disease; p.T240M (n = 1) and p.Q34fs delAG (n = 1). In addition, we identified 3 sEOAD individuals harboring a predicted pathogenic variant in MAPT (p.A469T), which has previously been associated with AD. It is currently unknown if these variants affect susceptibility to sEOAD, further studies would be needed to establish this. This work highlights the need to screen sEOAD individuals for variants that are more classically attributed to other forms of neurodegeneration.

Keywords: Alzheimer's disease; Early-onset; NeuroX; Parkinson's disease; Screening; Sporadic.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / genetics*
  • DNA Mutational Analysis / methods*
  • Genetic Association Studies*
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing
  • Genetic Variation / genetics*
  • Humans
  • Oligonucleotide Array Sequence Analysis / methods*
  • Parkinson Disease / genetics
  • Ubiquitin-Protein Ligases / genetics
  • tau Proteins / genetics

Substances

  • MAPT protein, human
  • tau Proteins
  • Ubiquitin-Protein Ligases
  • parkin protein