PLC-β1 and Cell Differentiation: An Insight Into Myogenesis and Osteogenesis

Adv Biol Regul. 2017 Jan;63:1-5. doi: 10.1016/j.jbior.2016.10.005. Epub 2016 Oct 18.

Abstract

Phosphoinositide-phospholipase C-β1 (PLC-β1) plays a crucial role in the initiation of the genetic program responsible for muscle differentiation and osteogenesis. During myogenic differentiation of murine C2C12 myoblasts, PLC-β1 signaling pathway involves the Inositol Polyphosphate Multikinase (IPMK) and β-catenin as downstream effectors. By means of c-jun binding to cyclin D3 promoter, the activation of PLC-β1 pathway determines cyclin D3 accumulation. However, osteogenesis requires PLC-β1 expression and up-regulation but it does not affect cyclin D3 levels, suggesting that the two processes require the activation of different mediators.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Line
  • Cyclin D3 / genetics
  • Cyclin D3 / metabolism
  • Gene Expression Regulation, Developmental
  • JNK Mitogen-Activated Protein Kinases / genetics
  • JNK Mitogen-Activated Protein Kinases / metabolism
  • Mice
  • Muscle Development / genetics*
  • Myoblasts / cytology
  • Myoblasts / metabolism*
  • Osteoblasts / cytology
  • Osteoblasts / metabolism*
  • Osteogenesis / genetics*
  • Phospholipase C beta / genetics*
  • Phospholipase C beta / metabolism
  • Phosphotransferases (Alcohol Group Acceptor) / genetics
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism
  • Promoter Regions, Genetic
  • Protein Binding
  • Signal Transduction
  • beta Catenin / genetics
  • beta Catenin / metabolism

Substances

  • CTNNB1 protein, mouse
  • Ccnd3 protein, mouse
  • Cyclin D3
  • beta Catenin
  • Phosphotransferases (Alcohol Group Acceptor)
  • inositol polyphosphate multikinase
  • JNK Mitogen-Activated Protein Kinases
  • Phospholipase C beta
  • Plcb1 protein, mouse