The first discovery of RNA interference by RNA restriction enzymes to inhibit protein synthesis

Gene. 2017 Jan 15:597:78-79. doi: 10.1016/j.gene.2016.10.025. Epub 2016 Oct 21.

Abstract

In this article, I review how an RNA restriction enzyme, a highly sequence-specific endoribonuclease, was for the first time discovered in 2003 and how the concept of RNA interference using RNA restriction enzymes or mRNA interferases has been developed.

Keywords: E. coli; RNA interference; RNA restriction enzymes; Single-Protein Production (SPP).

Publication types

  • Letter
  • Review

MeSH terms

  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Endoribonucleases / chemistry
  • Endoribonucleases / genetics
  • Endoribonucleases / metabolism*
  • Escherichia coli Proteins / chemistry
  • Escherichia coli Proteins / genetics
  • Escherichia coli Proteins / metabolism*
  • Protein Biosynthesis / genetics*
  • RNA Interference*

Substances

  • DNA-Binding Proteins
  • Escherichia coli Proteins
  • MazE protein, E coli
  • MazF protein, E coli
  • Endoribonucleases