The Clinical Application of Hydrogen as a Medical Treatment

Acta Med Okayama. 2016 Oct;70(5):331-337. doi: 10.18926/AMO/54590.


In recent years, it has become evident that molecular hydrogen is a particularyl effective treatment for various disease models such as ischemia-reperfusion injury; as a result, research on hydrogen has progressed rapidly. Hydrogen has been shown to be effective not only through intake as a gas, but also as a liquid medication taken orally, intravenously, or locally. Hydrogen's effectiveness is thus multifaceted. Herein we review the recent research on hydrogen-rich water, and we examine the possibilities for its clinical application. Now that hydrogen is in the limelight as a gaseous signaling molecule due to its potential ability to inhibit oxidative stress signaling, new research developments are highly anticipated.

Publication types

  • Review

MeSH terms

  • Antioxidants / therapeutic use
  • Gases / therapeutic use
  • Humans
  • Hydrogen / administration & dosage*
  • Hydrogen / chemistry
  • Hydrogen / pharmacology*
  • Oxidative Stress
  • Signal Transduction / physiology


  • Antioxidants
  • Gases
  • Hydrogen