RNA-Seeded Functional Amyloids Balance Growth and Survival

Dev Cell. 2016 Oct 24;39(2):131-132. doi: 10.1016/j.devcel.2016.10.005.


In this issue of Developmental Cell, Audas et al. (2016) report non-membrane-enclosed amyloid bodies (ABs) assembled in the nuclei of cells exposed to heat and low pH. Remarkably, ABs form not by liquid-to-liquid phase separation, implicated in RNA-seeded granule assembly, but by an amyloidogenic process that promotes a liquid-to-solid transition.

Publication types

  • Comment

MeSH terms

  • Amyloid*
  • RNA*


  • Amyloid
  • RNA