Membrane Trafficking: An Endosome Tether Meets a Rab and Collapses

Sanchaita Das; David G Lambright

doi:10.1016/j.cub.2016.08.056

Membrane Trafficking: An Endosome Tether Meets a Rab and Collapses

Curr Biol. 2016 Oct 24;26(20):R927-R929. doi: 10.1016/j.cub.2016.08.056.

Authors

Sanchaita Das¹, David G Lambright²

Affiliations

¹ Program in Molecular Medicine and Department of Biochemistry & Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
² Program in Molecular Medicine and Department of Biochemistry & Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: David.Lambright@umassmed.edu.

PMID: 27780062
DOI: 10.1016/j.cub.2016.08.056

Abstract

Long-range tethering is a ubiquitous recognition event preceding membrane fusion. A new study shows that Rab GTPase binding causes 'entropic collapse' of the coiled-coil endosome tether EEA1, driving membrane apposition and facilitating short-range interactions required for fusion.

Publication types

Comment

MeSH terms

Endosomes*
Membrane Fusion*
Protein Binding
Protein Transport