Abstract
Experiments were performed on the model of transplanted mouse tumor with high incidence of liver metastases. Hydrophilic drug cycloplatam (injected intravenously in liposomes) was more potent than "free cycloplatam" (injected intravenously or intraperitoneally in physiological saline) in inhibiting the growth of natural and experimental metastases in the liver. By contrast, liposomal cycloplatam had lower efficiency than free cycloplatam in suppressing the growth of solid tumor. Liposomal and free cortifen (hydrophobic hormonal cytostatic) produced nearly the same effects on solid tumor growth. Our results suggest that liposomal forms of hydrophobic compounds producing nonselective effect on tumor cells (e.g., actinomycin D or Cosmegen), should not have advantages over free forms.
Keywords:
cortifen; cycloplatam; liposomes; liver metastases; transplanted GA-1 tumor.
MeSH terms
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Animals
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Antineoplastic Agents / pharmacokinetics
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Corticosterone / analogs & derivatives*
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Corticosterone / pharmacokinetics
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Corticosterone / pharmacology
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Drug Delivery Systems
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Injections, Intraperitoneal
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Injections, Intravenous
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Liposomes / chemistry
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Liposomes / pharmacokinetics
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Liver Neoplasms / drug therapy*
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Liver Neoplasms / mortality
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Liver Neoplasms / secondary
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Mice
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Muscle Neoplasms / drug therapy*
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Muscle Neoplasms / mortality
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Muscle Neoplasms / pathology
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Neoplasm Transplantation
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Nitrogen Mustard Compounds / pharmacokinetics
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Nitrogen Mustard Compounds / pharmacology*
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Organoplatinum Compounds / pharmacokinetics
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Organoplatinum Compounds / pharmacology*
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Survival Analysis
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Treatment Outcome
Substances
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Antineoplastic Agents
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Liposomes
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Nitrogen Mustard Compounds
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Organoplatinum Compounds
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cortifen
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cycloplatam
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Corticosterone