On keeping the right ER size

Nat Cell Biol. 2016 Oct 27;18(11):1118-1119. doi: 10.1038/ncb3430.

Abstract

The endoplasmic reticulum (ER) is the largest membrane-bound organelle in cells, and its size needs to be carefully controlled. Downsizing the ER by autophagy is now shown to involve Sec62, a protein that also helps to build up the organelle. This link suggests a molecular switch for ER size control.

Publication types

  • Review

MeSH terms

  • Animals
  • Autophagy / physiology*
  • Endoplasmic Reticulum / metabolism*
  • Humans
  • Membrane Transport Proteins / metabolism*
  • Organelles / metabolism*
  • Protein Transport

Substances

  • Membrane Transport Proteins
  • SEC62 protein, human