Examining the protective effects of acetyl l-carnitine on cisplatin-induced uterine tube toxicity

J Obstet Gynaecol. 2016 Nov;36(8):1086-1092. doi: 10.1080/01443615.2016.1209174. Epub 2016 Oct 27.

Abstract

The aim of this study was to investigate the effects of cisplatin and the protective role of acetyl l-carnitine against uterine tube toxicity. Twenty-four female Wistar albino rats were divided into four groups: control group was injected with saline (control); group 2 was injected with acetyl l-carnitine; group 3 was injected with cisplatin; and group 4 was pre-treated with acetyl l-carnitine before cisplatin intraperitoneal injection. According to our results, a significant weight loss was observed in rats from group 3. The thickness of the wall and epithelium of uterine tube were decreased in group 3 rats. We elaborate the protein expression of caspase in epithelium and stroma by IHC. We found that the expression of caspase and the number of TUNEL-positive cells were increased in group 3 rats compared to the other groups. In our study, we showed the protective role of acetyl l-carnitine against uterine tube toxicity caused by cisplatin.

Keywords: Cisplatin; acetyl l-carnitine; apoptosis; uterine tube.

MeSH terms

  • Acetylcarnitine / pharmacology*
  • Animals
  • Antineoplastic Agents / toxicity*
  • Cisplatin / toxicity*
  • Fallopian Tubes / drug effects*
  • Fallopian Tubes / pathology
  • Female
  • Protective Agents / pharmacology
  • Rats
  • Rats, Wistar
  • Vitamin B Complex / pharmacology*

Substances

  • Antineoplastic Agents
  • Protective Agents
  • Vitamin B Complex
  • Acetylcarnitine
  • Cisplatin