Hypoxic regulation of neutrophil function and consequences for Staphylococcus aureus infection

Microbes Infect. 2017 Mar;19(3):166-176. doi: 10.1016/j.micinf.2016.10.005. Epub 2016 Oct 24.

Abstract

Staphylococcal infection and neutrophilic inflammation can act in concert to establish a profoundly hypoxic environment. In this review we summarise how neutrophils and Staphylococcus aureus are adapted to function under hypoxic conditions, with a particular focus on the impaired ability of hypoxic neutrophils to effect Staphylococcus aureus killing.

Keywords: Hypoxia; Neutrophil; Staphylococcus aureus.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Humans
  • Hypoxia / pathology*
  • Immunity, Innate*
  • Neutrophils / immunology*
  • Staphylococcal Infections / immunology*
  • Staphylococcal Infections / pathology*
  • Staphylococcus aureus / immunology*
  • Staphylococcus aureus / pathogenicity*