Hypoxic regulation of neutrophil function and consequences for Staphylococcus aureus infection

Katharine M Lodge; A A Roger Thompson; Edwin R Chilvers; Alison M Condliffe

doi:10.1016/j.micinf.2016.10.005

Hypoxic regulation of neutrophil function and consequences for Staphylococcus aureus infection

Microbes Infect. 2017 Mar;19(3):166-176. doi: 10.1016/j.micinf.2016.10.005. Epub 2016 Oct 24.

Authors

Katharine M Lodge¹, A A Roger Thompson², Edwin R Chilvers³, Alison M Condliffe²

Affiliations

¹ Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge University Hospitals, Hills Road, Cambridge, CB2 0QQ, UK.
² Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.
³ Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge University Hospitals, Hills Road, Cambridge, CB2 0QQ, UK. Electronic address: erc24@cam.ac.uk.

PMID: 27789256
DOI: 10.1016/j.micinf.2016.10.005

Abstract

Staphylococcal infection and neutrophilic inflammation can act in concert to establish a profoundly hypoxic environment. In this review we summarise how neutrophils and Staphylococcus aureus are adapted to function under hypoxic conditions, with a particular focus on the impaired ability of hypoxic neutrophils to effect Staphylococcus aureus killing.

Keywords: Hypoxia; Neutrophil; Staphylococcus aureus.

Publication types

Review

MeSH terms

Animals
Disease Models, Animal
Humans
Hypoxia / pathology*
Immunity, Innate*
Neutrophils / immunology*
Staphylococcal Infections / immunology*
Staphylococcal Infections / pathology*
Staphylococcus aureus / immunology*
Staphylococcus aureus / pathogenicity*

Grants and funding

G0802255/MRC_/Medical Research Council/United Kingdom