Platelets rich plasma versus minoxidil 5% in treatment of alopecia areata: A trichoscopic evaluation

Dermatol Ther. 2017 Jan;30(1). doi: 10.1111/dth.12437. Epub 2016 Oct 28.


Alopecia areata is a common cause of nonscarring alopecia that occurs in a patchy, confluent, or diffuse pattern. Dermoscopy is a noninvasive technique for the clinical diagnosis of many skin diseases. Topical minoxidil solution 5% and platelet rich plasma are important modalities used in treatment of alopecia areata. We aimed to evaluate the efficacy of PRP versus topical minoxidil 5% in the treatment of AA by clinical evaluation and trichoscopic examination. Ninety patients were allocated into three groups; the first was treated with topical minoxidil 5% solution, the second with platelets rich plasma injections, and the third with placebo. Diagnosis and follow up were done by serial digital camera photography of lesions and dermoscopic scan before and every 1 month after treatment for 3 months. Patients treated with minoxidil 5% and platelets rich plasma both have significant hair growth than placebo (p < .05). Patients treated with platelets rich plasma had an earlier response in the form of hair regrowth, reduction in short vellus hair and dystrophic hair unlike patients treated with minoxidil and control (p < .05). In conclusion, platelets rich plasma is more effective in the treatment of alopecia areata than topical minoxidil 5% as evaluated by clinical and trichoscopic examination.

Keywords: alopecia areata; platelets rich plasma; trichoscopy.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Alopecia Areata / diagnosis
  • Alopecia Areata / physiopathology
  • Alopecia Areata / therapy*
  • Child
  • Dermoscopy
  • Egypt
  • Female
  • Hair / drug effects*
  • Hair / growth & development
  • Humans
  • Male
  • Minoxidil / administration & dosage*
  • Photography
  • Platelet-Rich Plasma*
  • Time Factors
  • Treatment Outcome
  • Young Adult


  • Minoxidil