Multiple sclerosis in mothers of children with acute lymphoblastic leukemia

Leukemia. 1989 Oct;3(10):736-9.


The Childrens Cancer Study Group used data from a self-administered questionnaire to compare the observed and expected frequencies of multiple sclerosis (MS) in the parents of 1,027 children with acute lymphoblastic leukemia (ALL), 2,053 parents of children with other cancers, and in parents of 838 children without cancer. There were significant excesses seen for mothers of children with ALL (relative risk, RR = 4.0, p = 0.02), but no excess was found for acute nonlymphoblastic leukemia or lymphoma. There was no increase risk of MS for the fathers of these children.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Multiple Sclerosis / etiology
  • Multiple Sclerosis / genetics*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Surveys and Questionnaires