Hyperuricemia and coronary heart disease mortality: a meta-analysis of prospective cohort studies

BMC Cardiovasc Disord. 2016 Oct 28;16(1):207. doi: 10.1186/s12872-016-0379-z.


Background: Hyperuricemia may be associated with an increased risk of coronary heart disease (CHD) mortality; however, the results from prospective studies are conflicting. The objective of this study was to assess the association between hyperuricemia and risk of CHD mortality by performing a meta-analysis.

Methods: Pubmed and Embase were searched for relevant prospective cohort studies published until July 2015. Studies were included only if they reported data on CHD mortality related to hyperuricemia in a general population. The pooled adjusted relative risk (RR) was calculated using a random-effects model.

Results: A total of 14 studies involving 341 389 adults were identified. Hyperuricemia was associated with an increased risk of CHD mortality (RR: 1.14; 95 % CI: 1.06-1.23) and all-cause mortality (RR: 1.20; 95 % CI: 1.13-1.28). For each increase of 1 mg/dl of serum uric acid (SUA), the overall risks of CHD and all-cause mortality increased by 20 and 9 %, respectively. According to the gender subgroup analyses, hyperuricemia increased the risk of CHD mortality in women (RR: 1.47; 95 % CI: 1.21-1.73) compared to men (RR: 1.10; 95 % CI: 1.00-1.19). The risk of all-cause mortality was greater in women.

Conclusions: Hyperuricemia may modestly increase the risk of CHD and all-cause mortality. Future research is needed to determine whether urate-lowering therapy has beneficial effects for reducing CHD mortality.

Keywords: Coronary heart disease; Hyperuricemia; Meta-analysis; Mortality.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Coronary Artery Disease* / blood
  • Coronary Artery Disease* / epidemiology
  • Coronary Artery Disease* / etiology
  • Global Health
  • Humans
  • Hyperuricemia / blood
  • Hyperuricemia / complications*
  • Incidence
  • Prospective Studies
  • Risk Factors
  • Survival Rate / trends
  • Uric Acid / blood*


  • Uric Acid