A Disease or Not a Disease? Aging As a Pathology

Trends Mol Med. 2016 Dec;22(12):995-996. doi: 10.1016/j.molmed.2016.09.009. Epub 2016 Oct 25.


The debate on the relationship between aging and disease is centered on whether aging is a normal/natural/physiological process or it represents a pathology. Considering this relationship from medical, molecular, social, and historical perspectives, we argue that aging is neither a disease, nor a non-disease. Instead, it combines all age-related diseases and their preclinical forms, in addition to other pathological changes.

Keywords: aging; disease; pathology.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aging*
  • Disease / etiology*
  • Health*
  • Humans
  • Pathology*