doi: 10.1016/j.molmed.2016.10.001.
Epub 2016 Oct 25.
Is it Time to Fold the Cysts Away?
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- PMID: 27793600
- DOI: 10.1016/j.molmed.2016.10.001
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Is it Time to Fold the Cysts Away?
Trends Mol Med.
2016 Dec.
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in PKD1 and PKD2, encoding polycystin-1 and polycystin-2, respectively. Optimizing the folding environment for polycystin-1 missense mutations may have a critical effect on the progression of ADPKD in animal models and could potentially lead to tangible therapeutic options for subgroups of ADPKD patients.
Copyright © 2016 Elsevier Ltd. All rights reserved.
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